Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	GS1	9.62e-01	9.77e-01	9.89e-01	6.28e-02
GS1	EPI	5.54e-01	7.63e-01	4.62e-05	6.32e-01



Evaluating how well EPI genes are linked to GS1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	GS1	0.69	-0.54	-0.19	-0.53	2.39
GS1	EPI	0.49	-0.29	-0.57	-0.26	-0.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	GS1	0.00	-0.36	-0.25	-0.37	0.89
GS1	EPI	0.00	-0.15	-0.54	-0.30	-0.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	55	55	
GS1	12	11	Parkin