Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet113	GS	5.90e-01	8.73e-01	1.14e-04	8.62e-04
GS	wavelet113	5.84e-01	1.98e-01	5.15e-15	2.65e-16



Evaluating how well wavelet113 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet113	GS	0.84	0.95	1.23	1.74	4.80
GS	wavelet113	0.75	0.66	2.14	1.63	9.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet113	GS	0.00	-0.04	-5.54	2.56	10.43
GS	wavelet113	0.01	0.69	1.77	3.36	5.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet113	113	113	
GS	12	11	Parkin