Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet163	GS	7.37e-01	4.00e-01	2.20e-05	2.14e-05
GS	wavelet163	1.43e-01	2.11e-01	1.08e-19	2.13e-19



Evaluating how well wavelet163 genes are linked to GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet163	GS	0.88	1.69	2.00	2.37	4.95
GS	wavelet163	0.73	0.83	1.96	1.46	10.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet163	GS	0.00	-0.14	-3.08	2.32	6.18
GS	wavelet163	0.02	1.20	1.52	3.44	8.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet163	162	162	
GS	12	11	Parkin