Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML207 Exclusive	SS	1.91e-01	3.38e-01	1.41e-01	6.11e-01
SS Exclusive	EAML207	2.20e-01	7.68e-01	2.36e-02	4.10e-02
EAML207 Exclusive	SS Exclusive	8.59e-02	3.60e-01	6.67e-02	7.28e-01
SS Exclusive	EAML207 Exclusive	2.37e-01	6.22e-01	3.03e-02	5.97e-02
EAML207 Exclusive	Overlap	2.06e-01	2.06e-01	1.57e-01	5.10e-01
SS Exclusive	Overlap	1.18e-01	9.92e-02	1.12e-01	1.12e-01
Overlap	Exclusives	4.10e-03	6.06e-02	4.23e-10	1.47e-01



Evaluating how well EAML207 genes are linked to SS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML207 Exclusive	SS	0.50	-0.82	-0.94	-0.74	-0.05
SS Exclusive	EAML207	0.46	-0.96	-1.35	-0.68	-2.22
EAML207 Exclusive	SS Exclusive	0.48	-1.59	-1.57	-1.46	-0.32
SS Exclusive	EAML207 Exclusive	0.46	-0.94	-1.83	-1.11	-1.90
EAML207 Exclusive	Overlap	0.70	1.38	1.57	1.85	0.64
SS Exclusive	Overlap	1.00	5.35	6.76	3.98	1.75
Overlap	Exclusives	0.53	1.00	2.23	1.18	1.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML207 Exclusive	SS	0.00	-0.90	-0.47	-0.83	-0.12
SS Exclusive	EAML207	0.01	-1.11	-1.22	-0.69	-1.92
EAML207 Exclusive	SS Exclusive	0.00	-0.98	-0.92	-0.93	-0.47
SS Exclusive	EAML207 Exclusive	0.01	-1.04	-1.14	-1.17	-1.46
EAML207 Exclusive	Overlap	0.00	-0.11	-0.10	0.27	-0.20
SS Exclusive	Overlap	0.01	1.56	704.71	0.35	1.33
Overlap	Exclusives	0.01	1.43	4.52	1.62	4.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML207 Exclusive	206	204	PNMA6F;AL133500.1
SS Exclusive	10	10	
Overlap	1	1