Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML99	SS	3.26e-01	5.38e-01	2.49e-01	7.21e-01
SS	EAML99	8.90e-02	3.82e-01	9.18e-01	8.99e-02



Evaluating how well EAML99 genes are linked to SS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML99	SS	0.51	-0.64	-0.83	-0.83	0.08
SS	EAML99	0.44	-1.38	-1.89	-1.31	-1.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML99	SS	0.00	-0.73	-0.87	-0.54	-0.34
SS	EAML99	0.00	-0.69	-1.08	-0.88	-0.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML99	99	99	
SS	11	11