Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI128	SS	6.42e-01	7.27e-01	4.00e-01	9.20e-01
SS	EPI128	3.73e-01	8.21e-01	5.29e-01	4.24e-02



Evaluating how well EPI128 genes are linked to SS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI128	SS	0.50	-0.61	-0.89	-0.64	0.04
SS	EPI128	0.45	-0.97	-0.98	-0.94	-2.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI128	SS	0.00	-0.75	-0.38	-0.36	-0.19
SS	EPI128	0.01	-0.84	-1.09	-0.98	-1.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI128	128	127	AC010255.3
SS	11	11