Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI55	SS	9.70e-01	9.88e-01	9.62e-01	8.81e-01
SS	EPI55	8.36e-01	9.83e-01	8.94e-01	9.83e-01



Evaluating how well EPI55 genes are linked to SS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI55	SS	0.56	0.14	-0.11	0.15	0.57
SS	EPI55	0.50	-0.47	-0.14	-0.22	0.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI55	SS	0.00	-0.17	-0.37	-0.22	-0.14
SS	EPI55	0.00	-0.48	-0.24	-0.31	-0.20

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI55	55	55	
SS	11	11