Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wavelet113	SS	8.16e-01	3.11e-01	9.51e-04	8.40e-02
SS	Wavelet113	5.13e-01	6.01e-01	2.92e-02	7.13e-15



Evaluating how well Wavelet113 genes are linked to SS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet113	SS	0.65	1.29	1.41	1.72	1.67
SS	Wavelet113	0.72	0.37	-0.63	0.13	7.66

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet113	SS	0.00	0.11	0.85	0.64	0.37
SS	Wavelet113	0.01	0.68	0.13	0.37	4.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wavelet113	113	113	
SS	11	11