Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Wavelet 163 Exclusive	SS	9.98e-01	9.30e-01	2.72e-02	4.36e-01
SS Exclusive	Wavelet 163	5.86e-01	9.62e-01	2.34e-02	6.22e-22
Wavelet 163 Exclusive	SS Exclusive	1.00e+00	1.00e+00	6.33e-02	6.95e-01
SS Exclusive	Wavelet 163 Exclusive	5.78e-01	9.53e-01	3.14e-02	5.78e-22
Wavelet 163 Exclusive	Overlap	8.11e-01	2.06e-01	1.41e-01	2.28e-01
SS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	4.84e-06	2.75e-01	2.10e-19	2.36e-19



Evaluating how well Wavelet 163 genes are linked to SS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet 163 Exclusive	SS	0.61	0.52	0.40	0.39	1.11
SS Exclusive	Wavelet 163	0.71	0.31	-0.76	0.19	9.90
Wavelet 163 Exclusive	SS Exclusive	0.58	0.41	0.14	0.36	0.75
SS Exclusive	Wavelet 163 Exclusive	0.71	0.22	-0.66	0.18	9.09
Wavelet 163 Exclusive	Overlap	0.83	0.02	0.93	0.50	1.18
SS Exclusive	Overlap	1.00	2.81	3.83	2.04	1.75
Overlap	Exclusives	0.72	1.05	1.08	1.12	9.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Wavelet 163 Exclusive	SS	0.00	0.05	0.06	0.03	0.16
SS Exclusive	Wavelet 163	0.01	0.54	0.03	0.45	5.42
Wavelet 163 Exclusive	SS Exclusive	0.00	-0.10	-0.18	0.01	-0.10
SS Exclusive	Wavelet 163 Exclusive	0.01	0.18	-0.25	0.20	6.02
Wavelet 163 Exclusive	Overlap	0.00	-0.34	0.79	-0.21	-0.07
SS Exclusive	Overlap	0.01	65.21	221.51	37.17	47.28
Overlap	Exclusives	0.02	1.24	2.04	1.20	12.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Wavelet 163 Exclusive	161	161	
SS Exclusive	10	10	
Overlap	1	1