Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet243 Exclusive	SS	9.82e-01	9.96e-01	2.21e-02	2.93e-01
SS Exclusive	wavelet243	1.08e-01	8.25e-01	1.07e-02	2.86e-29
wavelet243 Exclusive	SS Exclusive	9.69e-01	9.90e-01	3.49e-02	4.53e-01
SS Exclusive	wavelet243 Exclusive	2.44e-01	6.87e-01	4.32e-03	3.93e-29
wavelet243 Exclusive	Overlap	2.06e-01	7.73e-01	1.33e-01	3.51e-01
SS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	1.35e-05	7.30e-01	2.48e-35	3.59e-22



Evaluating how well wavelet243 genes are linked to SS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet243 Exclusive	SS	0.61	-0.44	0.31	0.51	1.17
SS Exclusive	wavelet243	0.70	-0.26	-1.48	-0.32	10.24
wavelet243 Exclusive	SS Exclusive	0.59	-0.29	0.24	0.57	0.94
SS Exclusive	wavelet243 Exclusive	0.70	-0.01	-1.80	-0.20	11.43
wavelet243 Exclusive	Overlap	0.80	-0.97	0.21	0.28	0.89
SS Exclusive	Overlap	1.00	3.12	3.08	1.82	1.86
Overlap	Exclusives	0.70	0.60	0.07	0.88	11.57

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet243 Exclusive	SS	0.00	-1.20	-0.38	-0.12	0.06
SS Exclusive	wavelet243	0.02	0.14	-0.66	0.02	7.50
wavelet243 Exclusive	SS Exclusive	0.00	-0.98	-0.39	0.00	-0.11
SS Exclusive	wavelet243 Exclusive	0.02	0.16	-1.26	-0.04	8.52
wavelet243 Exclusive	Overlap	0.00	-0.86	-0.27	-0.27	-0.12
SS Exclusive	Overlap	0.01	81.26	191.86	32.63	29.74
Overlap	Exclusives	0.03	0.66	0.48	0.77	12.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet243 Exclusive	241	241	
SS Exclusive	10	10	
Overlap	1	1