Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI_FDR01 Exclusive	Tier1-Glycemic	1.99e-04	1.50e-04	2.76e-02	3.46e-08
Tier1-Glycemic Exclusive	EPI_FDR01	2.21e-01	2.65e-01	2.89e-04	5.25e-01
EPI_FDR01 Exclusive	Tier1-Glycemic Exclusive	1.06e-03	6.98e-04	3.73e-02	4.49e-08
Tier1-Glycemic Exclusive	EPI_FDR01 Exclusive	2.05e-01	5.19e-01	1.10e-03	3.64e-01
EPI_FDR01 Exclusive	Overlap	4.34e-02	5.78e-02	4.11e-02	5.49e-02
Tier1-Glycemic Exclusive	Overlap	2.57e-03	1.77e-02	1.68e-03	6.59e-03
Overlap	Exclusives	8.06e-05	4.32e-05	1.17e-09	7.26e-07



Evaluating how well EPI_FDR01 genes are linked to Tier1-Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_FDR01 Exclusive	Tier1-Glycemic	0.67	2.91	4.84	3.12	6.61
Tier1-Glycemic Exclusive	EPI_FDR01	0.51	2.16	1.74	1.08	0.65
EPI_FDR01 Exclusive	Tier1-Glycemic Exclusive	0.66	3.42	4.53	3.07	7.15
Tier1-Glycemic Exclusive	EPI_FDR01 Exclusive	0.50	1.89	1.16	0.78	-0.08
EPI_FDR01 Exclusive	Overlap	0.72	1.74	1.61	1.69	2.31
Tier1-Glycemic Exclusive	Overlap	0.91	4.83	3.22	3.41	3.31
Overlap	Exclusives	0.59	2.96	5.93	3.52	6.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_FDR01 Exclusive	Tier1-Glycemic	0.01	4.56	6.87	3.71	3.44
Tier1-Glycemic Exclusive	EPI_FDR01	0.03	40.70	36.60	25.99	26.53
EPI_FDR01 Exclusive	Tier1-Glycemic Exclusive	0.01	4.88	5.62	3.54	9.24
Tier1-Glycemic Exclusive	EPI_FDR01 Exclusive	0.02	17.77	12.24	10.60	9.58
EPI_FDR01 Exclusive	Overlap	0.00	6.90	4.56	2.49	0.38
Tier1-Glycemic Exclusive	Overlap	0.13	1208.09	136.40	976.94	337.40
Overlap	Exclusives	0.05	17.38	30.35	23.13	28.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI_FDR01 Exclusive	187	185	GCSAML-AS1;IQANK1
Tier1-Glycemic Exclusive	136	131	LOC157273;LOC101928448;LOC101928994;LINC00261;LOC440028
Overlap	5	5