Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI_FDR01 Exclusive	Tier2-Glycemic	1.76e-01	2.07e-01	6.34e-01	1.33e-02
Tier2-Glycemic Exclusive	EPI_FDR01	3.05e-01	3.82e-01	1.39e-02	2.14e-01
EPI_FDR01 Exclusive	Tier2-Glycemic Exclusive	3.28e-01	2.02e-01	8.64e-01	1.82e-02
Tier2-Glycemic Exclusive	EPI_FDR01 Exclusive	1.83e-01	5.55e-01	1.17e-02	2.07e-01
EPI_FDR01 Exclusive	Overlap	1.05e-01	9.92e-02	1.12e-01	1.18e-01
Tier2-Glycemic Exclusive	Overlap	1.57e-01	1.75e-01	1.85e-01	2.52e-01
Overlap	Exclusives	1.40e-06	4.77e-02	9.08e-04	4.91e-02



Evaluating how well EPI_FDR01 genes are linked to Tier2-Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_FDR01 Exclusive	Tier2-Glycemic	0.61	1.23	1.16	0.95	3.07
Tier2-Glycemic Exclusive	EPI_FDR01	0.49	0.01	0.57	0.01	-0.62
EPI_FDR01 Exclusive	Tier2-Glycemic Exclusive	0.60	0.67	1.15	0.57	2.42
Tier2-Glycemic Exclusive	EPI_FDR01 Exclusive	0.49	-0.33	0.17	-0.14	-0.59
EPI_FDR01 Exclusive	Overlap	0.98	2.09	2.12	1.88	1.88
Tier2-Glycemic Exclusive	Overlap	0.83	1.76	1.71	1.25	1.21
Overlap	Exclusives	0.54	1.92	2.90	1.58	2.30

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_FDR01 Exclusive	Tier2-Glycemic	0.00	2.11	0.47	1.50	0.62
Tier2-Glycemic Exclusive	EPI_FDR01	0.01	2.25	2.84	1.24	1.37
EPI_FDR01 Exclusive	Tier2-Glycemic Exclusive	0.00	1.14	0.05	0.92	2.07
Tier2-Glycemic Exclusive	EPI_FDR01 Exclusive	0.01	1.90	2.34	2.06	1.05
EPI_FDR01 Exclusive	Overlap	0.00	5.77	8.11	2.97	1.70
Tier2-Glycemic Exclusive	Overlap	0.00	-0.02	0.27	0.02	0.16
Overlap	Exclusives	0.02	2.82	4.21	2.62	2.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI_FDR01 Exclusive	191	189	GCSAML-AS1;IQANK1
Tier2-Glycemic Exclusive	57	53	ZNF664-FAM101A;TMEM110-MUSTN1;SERHL;LINC00885
Overlap	1	1