Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAW_FDR01 Exclusive	Tier1-Glycemic	9.63e-01	5.97e-01	3.79e-15	2.81e-08
Tier1-Glycemic Exclusive	EAW_FDR01	1.57e-02	6.35e-01	3.62e-12	2.51e-23
EAW_FDR01 Exclusive	Tier1-Glycemic Exclusive	9.44e-01	4.36e-01	4.94e-16	2.19e-08
Tier1-Glycemic Exclusive	EAW_FDR01 Exclusive	1.09e-02	8.88e-01	4.88e-10	7.39e-22
EAW_FDR01 Exclusive	Overlap	5.76e-01	3.73e-01	3.90e-02	7.98e-02
Tier1-Glycemic Exclusive	Overlap	7.26e-03	1.13e-02	2.90e-04	4.15e-04
Overlap	Exclusives	5.55e-02	3.96e-02	5.28e-41	1.13e-46



Evaluating how well EAW_FDR01 genes are linked to Tier1-Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAW_FDR01 Exclusive	Tier1-Glycemic	0.65	0.60	0.88	1.73	6.12
Tier1-Glycemic Exclusive	EAW_FDR01	0.71	-1.18	0.54	1.66	11.36
EAW_FDR01 Exclusive	Tier1-Glycemic Exclusive	0.64	0.89	0.90	2.06	5.01
Tier1-Glycemic Exclusive	EAW_FDR01 Exclusive	0.70	-1.45	0.19	1.34	11.82
EAW_FDR01 Exclusive	Overlap	0.74	-1.62	-0.71	0.64	1.88
Tier1-Glycemic Exclusive	Overlap	0.94	3.34	3.00	2.90	3.38
Overlap	Exclusives	0.72	1.72	4.42	2.12	15.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAW_FDR01 Exclusive	Tier1-Glycemic	0.01	1.29	1.81	2.55	9.11
Tier1-Glycemic Exclusive	EAW_FDR01	0.03	-0.56	3.37	3.94	20.14
EAW_FDR01 Exclusive	Tier1-Glycemic Exclusive	0.01	1.27	2.28	3.63	4.32
Tier1-Glycemic Exclusive	EAW_FDR01 Exclusive	0.03	-1.45	1.41	2.40	14.66
EAW_FDR01 Exclusive	Overlap	0.00	-1.30	-1.34	-0.04	0.05
Tier1-Glycemic Exclusive	Overlap	0.07	89.82	86.00	345.95	346.08
Overlap	Exclusives	0.05	4.89	11.22	6.98	26.85

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAW_FDR01 Exclusive	262	261	SPANXB1
Tier1-Glycemic Exclusive	136	131	LOC101928994;LINC00261;LOC101928448;LOC440028;LOC157273
Overlap	5	5