Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAW_FDR01 Exclusive	Tier2-Glycemic	7.93e-01	7.91e-01	8.49e-07	7.91e-03
Tier2-Glycemic Exclusive	EAW_FDR01	1.41e-01	1.07e-01	2.01e-10	1.19e-21
EAW_FDR01 Exclusive	Tier2-Glycemic Exclusive	9.35e-01	8.87e-01	7.37e-06	2.15e-02
Tier2-Glycemic Exclusive	EAW_FDR01 Exclusive	3.97e-01	2.21e-01	3.09e-11	2.27e-20
EAW_FDR01 Exclusive	Overlap	4.17e-01	1.33e-01	1.15e-02	1.82e-02
Tier2-Glycemic Exclusive	Overlap	1.06e-01	1.98e-01	3.69e-02	5.99e-02
Overlap	Exclusives	6.49e-10	1.04e-05	1.39e-59	7.89e-43



Evaluating how well EAW_FDR01 genes are linked to Tier2-Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAW_FDR01 Exclusive	Tier2-Glycemic	0.62	1.16	0.48	1.18	2.86
Tier2-Glycemic Exclusive	EAW_FDR01	0.69	0.63	1.66	1.72	10.98
EAW_FDR01 Exclusive	Tier2-Glycemic Exclusive	0.60	0.87	0.10	0.96	2.28
Tier2-Glycemic Exclusive	EAW_FDR01 Exclusive	0.69	0.39	1.38	1.84	10.67
EAW_FDR01 Exclusive	Overlap	0.97	1.83	1.22	2.44	2.45
Tier2-Glycemic Exclusive	Overlap	0.90	1.72	1.68	1.86	2.11
Overlap	Exclusives	0.75	2.71	5.35	2.33	13.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAW_FDR01 Exclusive	Tier2-Glycemic	0.01	1.34	1.26	5.37	1.36
Tier2-Glycemic Exclusive	EAW_FDR01	0.03	0.71	2.01	2.43	12.48
EAW_FDR01 Exclusive	Tier2-Glycemic Exclusive	0.00	0.49	0.10	3.41	3.47
Tier2-Glycemic Exclusive	EAW_FDR01 Exclusive	0.02	0.43	1.44	2.79	10.30
EAW_FDR01 Exclusive	Overlap	0.00	2.99	6.73	21.94	13.35
Tier2-Glycemic Exclusive	Overlap	0.00	2.75	2.07	3.20	1.58
Overlap	Exclusives	0.04	4.14	7.94	3.89	21.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAW_FDR01 Exclusive	265	264	SPANXB1
Tier2-Glycemic Exclusive	56	52	SERHL;ZNF664-FAM101A;LINC00885;TMEM110-MUSTN1
Overlap	2	2