Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_FDR01 Exclusive	Tier1-Glycemic	2.98e-02	1.49e-02	2.78e-01	5.58e-05
Tier1-Glycemic Exclusive	EAML_FDR01	2.29e-01	5.47e-01	1.12e-02	8.59e-01
EAML_FDR01 Exclusive	Tier1-Glycemic Exclusive	3.02e-02	1.62e-02	2.78e-01	1.09e-04
Tier1-Glycemic Exclusive	EAML_FDR01 Exclusive	5.53e-01	9.32e-01	1.24e-01	1.85e-01
EAML_FDR01 Exclusive	Overlap	5.84e-02	7.65e-02	1.30e-01	5.36e-02
Tier1-Glycemic Exclusive	Overlap	3.43e-03	1.10e-02	9.50e-04	4.30e-03
Overlap	Exclusives	3.00e-04	2.70e-04	4.09e-07	1.42e-06



Evaluating how well EAML_FDR01 genes are linked to Tier1-Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_FDR01 Exclusive	Tier1-Glycemic	0.64	2.38	3.26	1.70	5.79
Tier1-Glycemic Exclusive	EAML_FDR01	0.50	1.63	0.99	1.22	0.04
EAML_FDR01 Exclusive	Tier1-Glycemic Exclusive	0.63	2.04	2.78	1.55	5.01
Tier1-Glycemic Exclusive	EAML_FDR01 Exclusive	0.48	0.74	0.31	0.11	-0.88
EAML_FDR01 Exclusive	Overlap	0.73	2.17	1.85	1.92	2.06
Tier1-Glycemic Exclusive	Overlap	0.88	4.08	3.75	3.52	4.15
Overlap	Exclusives	0.60	3.86	5.71	4.59	6.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_FDR01 Exclusive	Tier1-Glycemic	0.01	3.31	3.70	2.05	5.63
Tier1-Glycemic Exclusive	EAML_FDR01	0.03	43.61	31.53	29.81	23.23
EAML_FDR01 Exclusive	Tier1-Glycemic Exclusive	0.01	2.60	3.01	1.75	5.99
Tier1-Glycemic Exclusive	EAML_FDR01 Exclusive	0.01	18.28	15.30	10.05	9.44
EAML_FDR01 Exclusive	Overlap	0.00	3.50	3.28	5.47	1.48
Tier1-Glycemic Exclusive	Overlap	0.10	474.11	160.16	537.24	223.29
Overlap	Exclusives	0.05	26.07	43.29	27.93	39.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_FDR01 Exclusive	158	152	IQANK1;ZNF816-ZNF321P;TSPY1;C22orf46;AGAP9;GCSAML-AS1
Tier1-Glycemic Exclusive	134	129	LOC157273;LOC101928448;LOC440028;LINC00261;LOC101928994
Overlap	7	7