Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_FDR01	Tier2-Glycemic	1.84e-01	1.15e-01	7.38e-01	5.77e-03
Tier2-Glycemic	EAML_FDR01	2.85e-01	3.42e-01	9.83e-03	7.05e-01



Evaluating how well EAML_FDR01 genes are linked to Tier2-Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_FDR01	Tier2-Glycemic	0.64	2.17	2.64	2.03	3.77
Tier2-Glycemic	EAML_FDR01	0.51	1.11	1.22	0.93	0.44

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_FDR01	Tier2-Glycemic	0.00	2.55	1.76	1.17	2.45
Tier2-Glycemic	EAML_FDR01	0.01	1.08	3.29	1.36	0.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_FDR01	165	159	ZNF816-ZNF321P;GCSAML-AS1;AGAP9;TSPY1;C22orf46;IQANK1
Tier2-Glycemic	58	54	LINC00885;TMEM110-MUSTN1;ZNF664-FAM101A;SERHL