Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Consensus2_FDR01 Exclusive	Tier2-T2D	3.64e-01	4.18e-01	1.63e-01	1.26e-01
Tier2-T2D Exclusive	Consensus2_FDR01	9.22e-01	9.58e-01	1.83e-01	1.64e-01
Consensus2_FDR01 Exclusive	Tier2-T2D Exclusive	4.27e-01	3.81e-01	1.70e-01	7.76e-02
Tier2-T2D Exclusive	Consensus2_FDR01 Exclusive	5.72e-01	9.86e-01	4.17e-01	2.34e-01
Consensus2_FDR01 Exclusive	Overlap	1.35e-02	1.35e-02	1.35e-02	1.40e-02
Tier2-T2D Exclusive	Overlap	1.06e-02	1.02e-02	1.02e-02	1.14e-02
Overlap	Exclusives	3.60e-03	2.26e-02	4.58e-05	3.07e-03



Evaluating how well Consensus2_FDR01 genes are linked to Tier2-T2D genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2_FDR01 Exclusive	Tier2-T2D	0.66	1.24	2.02	1.54	2.41
Tier2-T2D Exclusive	Consensus2_FDR01	0.56	0.57	0.53	0.31	1.67
Consensus2_FDR01 Exclusive	Tier2-T2D Exclusive	0.62	0.76	1.10	0.87	1.64
Tier2-T2D Exclusive	Consensus2_FDR01 Exclusive	0.54	-0.19	-0.06	-0.08	1.29
Consensus2_FDR01 Exclusive	Overlap	0.81	1.85	2.07	2.04	2.17
Tier2-T2D Exclusive	Overlap	0.88	3.17	3.00	2.41	2.51
Overlap	Exclusives	0.61	3.50	3.38	2.78	3.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2_FDR01 Exclusive	Tier2-T2D	0.00	1.76	3.00	2.70	2.63
Tier2-T2D Exclusive	Consensus2_FDR01	0.01	8.10	6.36	2.63	2.22
Consensus2_FDR01 Exclusive	Tier2-T2D Exclusive	0.00	-0.20	-0.05	-0.01	0.05
Tier2-T2D Exclusive	Consensus2_FDR01 Exclusive	0.00	0.87	0.14	0.52	0.38
Consensus2_FDR01 Exclusive	Overlap	0.00	7.58	17.08	9.89	5.47
Tier2-T2D Exclusive	Overlap	0.04	112.82	262.45	67.66	39.45
Overlap	Exclusives	0.01	13.89	14.05	5.00	13.16

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Consensus2_FDR01 Exclusive	79	77	GCSAML-AS1;IQANK1
Tier2-T2D Exclusive	12	12	
Overlap	4	4