Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Consensus2_FDR01	Tier2-Glycemic	2.44e-01	3.86e-01	1.10e-01	1.12e-01
Tier2-Glycemic	Consensus2_FDR01	3.40e-01	6.66e-01	4.33e-02	4.49e-01



Evaluating how well Consensus2_FDR01 genes are linked to Tier2-Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2_FDR01	Tier2-Glycemic	0.60	0.83	0.40	0.75	2.17
Tier2-Glycemic	Consensus2_FDR01	0.53	-1.10	-0.19	-0.22	1.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2_FDR01	Tier2-Glycemic	0.00	0.97	-0.00	0.17	1.94
Tier2-Glycemic	Consensus2_FDR01	0.01	1.01	2.17	1.53	0.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Consensus2_FDR01	83	81	IQANK1;GCSAML-AS1
Tier2-Glycemic	58	54	LINC00885;TMEM110-MUSTN1;SERHL;ZNF664-FAM101A