Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI_FDR001 Exclusive	Tier1-Glycemic	1.04e-06	3.14e-07	9.64e-05	1.50e-11
Tier1-Glycemic Exclusive	EPI_FDR001	3.72e-02	4.06e-02	1.38e-03	1.44e-01
EPI_FDR001 Exclusive	Tier1-Glycemic Exclusive	1.00e-06	3.12e-07	4.18e-05	5.66e-12
Tier1-Glycemic Exclusive	EPI_FDR001 Exclusive	2.09e-01	5.43e-02	1.30e-02	2.95e-01
EPI_FDR001 Exclusive	Overlap	8.41e-01	9.54e-01	9.84e-01	8.41e-01
Tier1-Glycemic Exclusive	Overlap	2.02e-02	5.93e-02	1.22e-02	2.23e-02
Overlap	Exclusives	8.19e-06	4.58e-06	1.25e-10	9.11e-12



Evaluating how well EPI_FDR001 genes are linked to Tier1-Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_FDR001 Exclusive	Tier1-Glycemic	0.67	2.85	5.94	2.80	6.86
Tier1-Glycemic Exclusive	EPI_FDR001	0.58	3.99	3.17	2.94	2.29
EPI_FDR001 Exclusive	Tier1-Glycemic Exclusive	0.68	3.66	5.27	3.15	7.13
Tier1-Glycemic Exclusive	EPI_FDR001 Exclusive	0.56	3.29	3.18	2.56	1.66
EPI_FDR001 Exclusive	Overlap	0.57	0.47	0.18	0.01	0.48
Tier1-Glycemic Exclusive	Overlap	0.89	3.50	3.15	3.21	2.81
Overlap	Exclusives	0.66	2.63	6.10	3.05	7.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_FDR001 Exclusive	Tier1-Glycemic	0.01	2.85	5.06	2.25	6.93
Tier1-Glycemic Exclusive	EPI_FDR001	0.01	29.51	13.87	22.03	20.12
EPI_FDR001 Exclusive	Tier1-Glycemic Exclusive	0.01	4.01	5.09	2.80	3.07
Tier1-Glycemic Exclusive	EPI_FDR001 Exclusive	0.00	4.36	2.43	1.83	2.44
EPI_FDR001 Exclusive	Overlap	0.00	-0.13	-0.33	-0.34	-0.18
Tier1-Glycemic Exclusive	Overlap	0.09	601.75	110.50	408.70	629.54
Overlap	Exclusives	0.04	12.23	36.37	19.19	23.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI_FDR001 Exclusive	57	56	GCSAML-AS1
Tier1-Glycemic Exclusive	137	132	LOC440028;LOC101928448;LINC00261;LOC157273;LOC101928994
Overlap	4	4