Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI_FDR001	Tier2-Glycemic	7.06e-01	7.99e-01	2.78e-01	5.34e-02
Tier2-Glycemic	EPI_FDR001	3.15e-01	3.96e-01	1.94e-01	4.25e-01



Evaluating how well EPI_FDR001 genes are linked to Tier2-Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_FDR001	Tier2-Glycemic	0.56	-0.10	-0.34	-0.56	1.53
Tier2-Glycemic	EPI_FDR001	0.48	-0.66	0.07	-0.50	-0.43

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_FDR001	Tier2-Glycemic	0.00	-0.16	-0.78	-0.66	0.56
Tier2-Glycemic	EPI_FDR001	0.00	-0.56	-0.20	-0.44	-0.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI_FDR001	61	60	GCSAML-AS1
Tier2-Glycemic	58	54	LINC00885;ZNF664-FAM101A;TMEM110-MUSTN1;SERHL