Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Consensus Exclusive	GoldStandard	1.19e-01	8.86e-02	3.00e-06	2.81e-09
GoldStandard Exclusive	Consensus	1.99e-02	8.66e-02	2.50e-08	1.70e-07
Consensus Exclusive	GoldStandard Exclusive	3.13e-01	1.34e-01	2.76e-05	3.82e-07
GoldStandard Exclusive	Consensus Exclusive	1.11e-01	9.73e-02	2.63e-07	4.17e-06
Consensus Exclusive	Overlap	1.30e-03	1.30e-03	1.33e-04	3.45e-05
GoldStandard Exclusive	Overlap	2.10e-05	2.10e-05	2.10e-05	2.10e-05
Overlap	Exclusives	3.16e-06	5.70e-05	2.45e-32	1.28e-08



Evaluating how well Consensus genes are linked to GoldStandard genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus Exclusive	GoldStandard	0.79	2.87	3.14	2.95	6.37
GoldStandard Exclusive	Consensus	0.65	2.08	2.83	2.87	6.09
Consensus Exclusive	GoldStandard Exclusive	0.77	2.56	3.11	2.91	5.52
GoldStandard Exclusive	Consensus Exclusive	0.64	1.84	2.63	2.43	5.60
Consensus Exclusive	Overlap	0.99	1.80	2.96	2.05	4.50
GoldStandard Exclusive	Overlap	1.00	2.16	2.67	2.31	3.99
Overlap	Exclusives	0.64	3.06	2.27	1.19	6.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus Exclusive	GoldStandard	0.01	0.32	7.91	4.64	17.27
GoldStandard Exclusive	Consensus	0.03	14.77	13.55	15.19	16.85
Consensus Exclusive	GoldStandard Exclusive	0.01	-0.11	2.34	3.51	1.85
GoldStandard Exclusive	Consensus Exclusive	0.01	1.38	1.21	2.58	4.96
Consensus Exclusive	Overlap	0.02	-0.21	52.71	7.43	13.45
GoldStandard Exclusive	Overlap	0.30	56.96	418.20	500.03	908.03
Overlap	Exclusives	0.04	17.52	22.06	13.66	35.76

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Consensus Exclusive	147	145	C20orf141;CCDC7
GoldStandard Exclusive	48	41	RNU6-1224P;PCAT1;RN7SL468P;LINC02257;CASP3P1;CASC8;CHORDC1P5
Overlap	5	5