Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
epi_rare_q01	GoldStandard	9.80e-01	3.65e-01	7.86e-01	3.06e-05
GoldStandard	epi_rare_q01	5.61e-02	9.52e-01	9.25e-03	7.05e-01



Evaluating how well epi_rare_q01 genes are linked to GoldStandard genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi_rare_q01	GoldStandard	0.70	0.05	1.44	0.58	4.66
GoldStandard	epi_rare_q01	0.52	1.27	0.53	0.38	0.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
epi_rare_q01	GoldStandard	0.00	-0.85	0.82	-0.38	3.15
GoldStandard	epi_rare_q01	0.01	0.67	-0.03	-0.06	0.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
epi_rare_q01	151	150	CCDC7
GoldStandard	53	46	RNU6-1224P;CHORDC1P5;CASP3P1;CASC8;RN7SL468P;PCAT1;LINC02257