Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
wavelet_rare_q01 Exclusive	GoldStandard	2.53e-01	4.26e-02	2.39e-13	7.06e-10
GoldStandard Exclusive	wavelet_rare_q01	5.64e-04	1.47e-02	7.94e-23	8.51e-30
wavelet_rare_q01 Exclusive	GoldStandard Exclusive	2.65e-01	3.90e-02	7.40e-14	2.02e-09
GoldStandard Exclusive	wavelet_rare_q01 Exclusive	7.23e-04	1.21e-02	4.36e-24	6.29e-29
wavelet_rare_q01 Exclusive	Overlap	1.05e-01	9.92e-02	9.92e-02	9.92e-02
GoldStandard Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	2.03e-02	3.84e-07	8.44e-86	1.22e-36



Evaluating how well wavelet_rare_q01 genes are linked to GoldStandard genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet_rare_q01 Exclusive	GoldStandard	0.79	1.82	2.41	2.71	6.97
GoldStandard Exclusive	wavelet_rare_q01	0.80	0.28	3.68	3.69	12.69
wavelet_rare_q01 Exclusive	GoldStandard Exclusive	0.78	1.89	2.20	3.31	6.15
GoldStandard Exclusive	wavelet_rare_q01 Exclusive	0.79	0.43	3.78	3.62	12.12
wavelet_rare_q01 Exclusive	Overlap	1.00	-6.82	468831941222.00	0.97	1.72
GoldStandard Exclusive	Overlap	1.00	0.58	51030527439028.34	1.24	1.82
Overlap	Exclusives	0.78	257021123030282.00	5.39	1.35	13.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
wavelet_rare_q01 Exclusive	GoldStandard	0.02	-1.11	4.31	9.61	7.50
GoldStandard Exclusive	wavelet_rare_q01	0.03	-0.23	3.59	7.90	15.36
wavelet_rare_q01 Exclusive	GoldStandard Exclusive	0.02	-0.34	4.73	9.39	5.93
GoldStandard Exclusive	wavelet_rare_q01 Exclusive	0.02	-0.21	3.13	6.89	9.29
wavelet_rare_q01 Exclusive	Overlap	0.02	-0.94	230953827044641.50	0.81	81.91
GoldStandard Exclusive	Overlap	0.03	-0.08	114715077661473008.00	11.04	123.48
Overlap	Exclusives	0.02	1113158525171828.00	7.15	1.23	19.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
wavelet_rare_q01 Exclusive	131	131	
GoldStandard Exclusive	52	45	PCAT1;CASP3P1;RN7SL468P;RNU6-1224P;LINC02257;CASC8;CHORDC1P5
Overlap	1	1