Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
reactome_AC5 Exclusive	GoldStandard	9.85e-03	1.79e-02	4.23e-08	3.33e-09
GoldStandard Exclusive	reactome_AC5	7.21e-05	3.36e-02	1.10e-08	5.00e-14
reactome_AC5 Exclusive	GoldStandard Exclusive	1.24e-01	2.84e-01	8.52e-05	4.18e-05
GoldStandard Exclusive	reactome_AC5 Exclusive	5.15e-04	1.27e-01	1.13e-07	1.62e-13
reactome_AC5 Exclusive	Overlap	1.46e-04	5.11e-04	1.74e-06	2.14e-07
GoldStandard Exclusive	Overlap	4.29e-08	4.29e-08	4.29e-08	4.64e-08
Overlap	Exclusives	1.77e-15	6.59e-13	4.50e-89	1.33e-32



Evaluating how well reactome_AC5 genes are linked to GoldStandard genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
reactome_AC5 Exclusive	GoldStandard	0.75	0.49	2.38	1.27	5.37
GoldStandard Exclusive	reactome_AC5	0.62	0.50	-0.03	0.40	9.66
reactome_AC5 Exclusive	GoldStandard Exclusive	0.68	-0.77	0.84	0.51	4.00
GoldStandard Exclusive	reactome_AC5 Exclusive	0.61	0.69	-0.33	0.34	8.00
reactome_AC5 Exclusive	Overlap	0.97	2.76	3.95	2.65	4.97
GoldStandard Exclusive	Overlap	0.93	1.90	2.95	2.57	5.47
Overlap	Exclusives	0.70	3.36	9.02	2.62	14.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
reactome_AC5 Exclusive	GoldStandard	0.01	-1.24	1.81	0.36	3.77
GoldStandard Exclusive	reactome_AC5	0.04	4.42	10.18	4.38	22.65
reactome_AC5 Exclusive	GoldStandard Exclusive	0.00	-1.93	0.03	-0.34	4.00
GoldStandard Exclusive	reactome_AC5 Exclusive	0.03	1.22	2.67	2.13	9.23
reactome_AC5 Exclusive	Overlap	0.02	-0.83	20.55	0.23	10.55
GoldStandard Exclusive	Overlap	0.19	51.44	232.14	252.72	555.15
Overlap	Exclusives	0.08	13.53	41.08	11.80	52.00

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
reactome_AC5 Exclusive	418	418	
GoldStandard Exclusive	43	36	CHORDC1P5;LINC02257;CASC8;PCAT1;CASP3P1;RNU6-1224P;RN7SL468P
Overlap	10	10