Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
consensus	Juan	9.72e-01	8.44e-01	5.24e-01	1.35e-03
Juan	consensus	5.85e-01	6.39e-01	1.88e-06	4.28e-01



Evaluating how well consensus genes are linked to Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus	Juan	0.76	0.05	0.15	0.51	3.23
Juan	consensus	0.50	-0.64	-0.64	-0.45	0.19

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus	Juan	0.00	-0.29	-0.39	0.07	0.92
Juan	consensus	0.01	-0.37	-0.50	-0.15	0.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
consensus	100	100	
Juan	12	12