Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
consensus	Juan	9.92e-01	9.72e-01	4.95e-01	2.76e-03
Juan	consensus	6.20e-01	6.90e-01	7.29e-06	3.79e-01



Evaluating how well consensus genes are linked to Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus	Juan	0.76	0.01	0.01	0.50	3.32
Juan	consensus	0.50	-0.61	-0.63	-0.43	0.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus	Juan	0.00	-0.42	-0.49	-0.00	1.36
Juan	consensus	0.01	-0.22	-0.51	-0.19	0.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
consensus	100	100	
Juan	12	12