Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
metaserver	Juan	5.82e-01	6.38e-01	6.75e-02	3.91e-04
Juan	metaserver	1.38e-01	8.69e-01	1.58e-12	8.06e-02



Evaluating how well metaserver genes are linked to Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
metaserver	Juan	0.84	1.25	1.99	1.68	3.85
Juan	metaserver	0.55	-0.22	-0.60	-0.17	2.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
metaserver	Juan	0.00	-0.50	-2.36	0.49	1.47
Juan	metaserver	0.01	0.52	-0.06	0.52	1.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
metaserver	170	170	
Juan	12	12