Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
consensus	juan	9.94e-01	9.21e-01	4.27e-01	1.55e-03
juan	consensus	5.37e-01	7.42e-01	5.54e-06	3.81e-01



Evaluating how well consensus genes are linked to juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus	juan	0.76	0.01	0.07	0.61	3.21
juan	consensus	0.50	-0.82	-0.56	-0.27	0.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus	juan	0.00	-0.40	-0.59	0.05	2.10
juan	consensus	0.01	-0.53	-0.50	-0.15	0.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
consensus	100	100	
juan	12	12