Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	Juan	6.65e-02	3.49e-01	1.24e-01	7.39e-03
Juan	EAML	1.02e-01	2.71e-01	1.06e-14	1.20e-01



Evaluating how well EAML genes are linked to Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	Juan	0.72	-1.04	-0.37	-0.70	2.29
Juan	EAML	0.46	-1.22	-2.04	-1.17	-1.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	Juan	0.00	-0.97	-0.80	-1.03	1.36
Juan	EAML	0.01	-0.50	-1.41	-0.80	-1.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	199	199	
Juan	12	12