Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	JUAN	7.77e-01	9.72e-01	7.53e-01	4.45e-02
JUAN	EPI	9.20e-01	8.53e-01	4.96e-10	4.86e-02



Evaluating how well EPI genes are linked to JUAN genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	JUAN	0.70	-0.97	-0.50	-0.65	2.21
JUAN	EPI	0.46	0.15	-0.73	-0.74	-1.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	JUAN	0.00	-0.56	-0.11	-0.58	0.75
JUAN	EPI	0.01	-0.07	-0.88	-0.66	-1.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	138	138	
JUAN	12	12