Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
metaserver	Juan	7.13e-01	6.33e-01	6.65e-02	2.90e-04
Juan	metaserver	1.75e-01	9.09e-01	1.77e-13	6.03e-02



Evaluating how well metaserver genes are linked to Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
metaserver	Juan	0.84	1.28	1.79	1.51	4.13
Juan	metaserver	0.55	-0.01	-0.48	-0.16	2.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
metaserver	Juan	0.00	-0.35	-2.26	0.37	4.78
Juan	metaserver	0.01	0.57	0.07	0.59	2.27

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
metaserver	170	170	
Juan	12	12