Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
vep_2method_RareCon_AC1	AD-Final25	7.82e-02	6.12e-02	7.41e-04	7.75e-05
AD-Final25	vep_2method_RareCon_AC1	3.44e-01	4.82e-02	1.83e-03	1.43e-04



Evaluating how well vep_2method_RareCon_AC1 genes are linked to AD-Final25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
vep_2method_RareCon_AC1	AD-Final25	0.74	1.85	2.56	2.21	4.20
AD-Final25	vep_2method_RareCon_AC1	0.60	1.39	2.00	1.43	3.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
vep_2method_RareCon_AC1	AD-Final25	0.00	1.43	2.37	2.15	4.31
AD-Final25	vep_2method_RareCon_AC1	0.01	1.43	2.83	2.34	3.74

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
vep_2method_RareCon_AC1	126	125	PRAMEF11
AD-Final25	25	25