Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All-Familial Exclusive	VEPRare2MethodConsensusAC1	9.81e-03	5.55e-02	1.91e-06	1.19e-03
VEPRare2MethodConsensusAC1 Exclusive	All-Familial	3.96e-04	1.85e-04	7.83e-10	7.69e-15
All-Familial Exclusive	VEPRare2MethodConsensusAC1 Exclusive	2.41e-03	3.60e-01	2.34e-04	3.90e-03
VEPRare2MethodConsensusAC1 Exclusive	All-Familial Exclusive	1.98e-03	1.20e-03	6.50e-07	4.29e-12
All-Familial Exclusive	Overlap	4.18e-08	4.37e-08	4.18e-08	4.37e-08
VEPRare2MethodConsensusAC1 Exclusive	Overlap	7.43e-03	4.47e-03	2.53e-04	2.54e-06
Overlap	Exclusives	6.82e-08	1.67e-07	3.17e-15	3.03e-12



Evaluating how well All-Familial genes are linked to VEPRare2MethodConsensusAC1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All-Familial Exclusive	VEPRare2MethodConsensusAC1	0.62	1.84	1.96	2.17	4.02
VEPRare2MethodConsensusAC1 Exclusive	All-Familial	0.84	2.90	4.66	2.67	9.12
All-Familial Exclusive	VEPRare2MethodConsensusAC1 Exclusive	0.59	1.14	1.31	1.57	3.10
VEPRare2MethodConsensusAC1 Exclusive	All-Familial Exclusive	0.83	2.59	3.83	2.67	8.21
All-Familial Exclusive	Overlap	1.00	3.10	4.24	2.15	4.51
VEPRare2MethodConsensusAC1 Exclusive	Overlap	0.96	1.86	3.19	2.06	4.20
Overlap	Exclusives	0.69	3.27	4.18	3.01	8.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All-Familial Exclusive	VEPRare2MethodConsensusAC1	0.03	14.80	31.74	30.35	35.17
VEPRare2MethodConsensusAC1 Exclusive	All-Familial	0.02	2.67	10.19	5.20	25.02
All-Familial Exclusive	VEPRare2MethodConsensusAC1 Exclusive	0.01	4.19	2.20	4.81	2.89
VEPRare2MethodConsensusAC1 Exclusive	All-Familial Exclusive	0.01	1.64	6.70	4.74	12.83
All-Familial Exclusive	Overlap	0.16	62.11	312.22	163.58	627.01
VEPRare2MethodConsensusAC1 Exclusive	Overlap	0.01	1.82	13.42	6.47	26.04
Overlap	Exclusives	0.04	14.20	26.49	21.39	45.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All-Familial Exclusive	52	52	
VEPRare2MethodConsensusAC1 Exclusive	118	117	PRAMEF11
Overlap	8	8