Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MI-Pathogenic Exclusive	VEPRare2MethodConsensusAC1	3.17e-04	2.45e-04	4.34e-08	2.29e-05
VEPRare2MethodConsensusAC1 Exclusive	MI-Pathogenic	4.55e-03	6.59e-03	8.56e-05	8.54e-09
MI-Pathogenic Exclusive	VEPRare2MethodConsensusAC1 Exclusive	1.43e-03	8.40e-04	1.74e-07	6.35e-05
VEPRare2MethodConsensusAC1 Exclusive	MI-Pathogenic Exclusive	1.75e-02	3.09e-02	1.23e-04	7.73e-08
MI-Pathogenic Exclusive	Overlap	2.80e-02	8.69e-02	1.22e-02	1.82e-02
VEPRare2MethodConsensusAC1 Exclusive	Overlap	2.00e-02	1.15e-02	1.82e-02	1.91e-02
Overlap	Exclusives	2.68e-04	2.19e-04	7.67e-34	2.16e-13



Evaluating how well MI-Pathogenic genes are linked to VEPRare2MethodConsensusAC1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MI-Pathogenic Exclusive	VEPRare2MethodConsensusAC1	0.63	3.29	3.92	2.68	4.93
VEPRare2MethodConsensusAC1 Exclusive	MI-Pathogenic	0.80	2.22	4.26	2.67	6.51
MI-Pathogenic Exclusive	VEPRare2MethodConsensusAC1 Exclusive	0.62	2.94	3.02	2.66	4.57
VEPRare2MethodConsensusAC1 Exclusive	MI-Pathogenic Exclusive	0.79	2.46	4.07	2.29	5.75
MI-Pathogenic Exclusive	Overlap	0.97	1.34	2.12	2.53	2.20
VEPRare2MethodConsensusAC1 Exclusive	Overlap	0.96	1.66	2.79	1.75	1.99
Overlap	Exclusives	0.68	2.81	5.26	2.10	8.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MI-Pathogenic Exclusive	VEPRare2MethodConsensusAC1	0.01	3.11	5.91	5.11	8.37
VEPRare2MethodConsensusAC1 Exclusive	MI-Pathogenic	0.01	3.53	9.75	4.24	10.77
MI-Pathogenic Exclusive	VEPRare2MethodConsensusAC1 Exclusive	0.01	2.88	4.05	2.51	3.16
VEPRare2MethodConsensusAC1 Exclusive	MI-Pathogenic Exclusive	0.01	4.58	10.63	4.68	7.40
MI-Pathogenic Exclusive	Overlap	0.00	2.55	11.14	15.76	10.10
VEPRare2MethodConsensusAC1 Exclusive	Overlap	0.00	1.31	11.33	1.27	1.80
Overlap	Exclusives	0.02	9.45	11.37	4.04	16.43

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MI-Pathogenic Exclusive	37	37	
VEPRare2MethodConsensusAC1 Exclusive	124	123	PRAMEF11
Overlap	2	2