Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
125 genes	Juan	2.44e-02	3.28e-02	4.80e-05	6.79e-07
Juan	125 genes	5.61e-01	6.15e-01	2.55e-09	3.01e-03



Evaluating how well 125 genes genes are linked to Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125 genes	Juan	0.91	2.04	3.47	2.75	5.55
Juan	125 genes	0.58	0.62	-0.04	0.18	3.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125 genes	Juan	0.00	0.57	2.64	3.04	6.95
Juan	125 genes	0.01	4.07	1.85	1.45	4.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
125 genes	125	125	
Juan	12	12