Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
125genes Exclusive	singletons	1.15e-01	2.20e-01	1.49e-01	7.57e-04
singletons Exclusive	125genes	8.07e-01	6.29e-01	3.23e-06	5.96e-03
125genes Exclusive	singletons Exclusive	1.37e-01	2.43e-01	6.87e-02	1.46e-03
singletons Exclusive	125genes Exclusive	5.01e-01	5.48e-01	1.62e-05	1.00e-02
125genes Exclusive	Overlap	8.69e-02	2.75e-01	4.89e-01	2.93e-01
singletons Exclusive	Overlap	1.22e-02	1.15e-02	1.15e-02	1.15e-02
Overlap	Exclusives	1.25e-03	3.78e-02	4.29e-11	1.42e-05



Evaluating how well 125genes genes are linked to singletons genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125genes Exclusive	singletons	0.73	-0.46	0.14	0.68	3.53
singletons Exclusive	125genes	0.57	0.26	-0.75	0.37	2.64
125genes Exclusive	singletons Exclusive	0.74	-0.23	0.51	0.62	3.24
singletons Exclusive	125genes Exclusive	0.56	-0.21	-1.05	-0.11	2.18
125genes Exclusive	Overlap	0.61	-2.00	-0.72	-0.66	0.70
singletons Exclusive	Overlap	1.00	2.78	3.36	2.72	2.64
Overlap	Exclusives	0.61	1.67	0.52	1.01	4.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125genes Exclusive	singletons	0.00	-1.13	-0.95	-0.21	2.12
singletons Exclusive	125genes	0.01	0.81	0.35	1.81	1.49
125genes Exclusive	singletons Exclusive	0.00	-0.99	-1.01	-0.23	1.60
singletons Exclusive	125genes Exclusive	0.01	-0.22	-0.92	0.16	0.81
125genes Exclusive	Overlap	0.00	-0.99	-0.88	-0.73	-0.22
singletons Exclusive	Overlap	0.03	9.12	471.22	145.11	215.66
Overlap	Exclusives	0.01	4.60	1.79	2.96	8.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
125genes Exclusive	123	123	
singletons Exclusive	18	18	
Overlap	2	2