Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML	JuanGS	8.65e-01	4.72e-01	7.72e-01	1.88e-04
JuanGS	EAML	4.74e-01	3.21e-01	6.54e-09	3.06e-01



Evaluating how well EAML genes are linked to JuanGS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	JuanGS	0.79	0.67	1.47	0.81	3.54
JuanGS	EAML	0.47	0.11	-0.67	-0.54	-1.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML	JuanGS	0.00	-0.16	0.86	-0.13	0.41
JuanGS	EAML	0.01	0.68	-0.08	-0.05	-0.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML	101	101	
JuanGS	12	12