Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI	Juan GS	1.70e-01	5.63e-01	1.53e-01	1.80e-01
Juan GS	EPI	2.53e-01	2.39e-01	9.69e-04	5.37e-02



Evaluating how well EPI genes are linked to Juan GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Juan GS	0.63	-1.53	-1.29	-1.30	1.65
Juan GS	EPI	0.43	-1.71	-1.97	-1.64	-1.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI	Juan GS	0.00	-0.84	-1.09	-0.99	-0.02
Juan GS	EPI	0.00	-0.26	-0.97	-0.89	-1.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI	49	49	
Juan GS	12	12