Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
125genes	Juan	3.64e-02	1.93e-02	4.80e-05	1.30e-06
Juan	125genes	6.09e-01	6.73e-01	1.87e-09	1.81e-03



Evaluating how well 125genes genes are linked to Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125genes	Juan	0.91	1.93	3.86	2.73	4.75
Juan	125genes	0.58	0.80	-0.15	0.25	3.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125genes	Juan	0.00	0.24	4.19	2.69	3.18
Juan	125genes	0.01	4.13	1.66	2.53	5.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
125genes	125	125	
Juan	12	12