Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML Exclusive	GWAS	9.87e-01	9.42e-01	9.08e-01	4.46e-02
GWAS Exclusive	EAML	7.83e-01	6.69e-01	2.88e-01	5.34e-01
EAML Exclusive	GWAS Exclusive	9.95e-01	9.33e-01	9.62e-01	3.97e-02
GWAS Exclusive	EAML Exclusive	6.59e-01	4.27e-01	3.32e-01	5.48e-01
EAML Exclusive	Overlap	3.67e-01	3.20e-01	2.40e-01	1.75e-01
GWAS Exclusive	Overlap	9.92e-02	9.92e-02	9.92e-02	9.92e-02
Overlap	Exclusives	6.59e-02	1.95e-02	1.35e-08	2.89e-02



Evaluating how well EAML genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	GWAS	0.58	0.30	0.27	0.16	2.58
GWAS Exclusive	EAML	0.48	-0.23	-0.08	-0.43	-0.48
EAML Exclusive	GWAS Exclusive	0.59	0.41	0.33	0.23	2.77
GWAS Exclusive	EAML Exclusive	0.48	-0.58	-0.56	-0.64	-0.62
EAML Exclusive	Overlap	0.10	-0.83	-0.69	-1.09	-1.27
GWAS Exclusive	Overlap	1.00	3.16	2.16	2.29	1.63
Overlap	Exclusives	0.53	-0.59	0.30	-0.61	1.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML Exclusive	GWAS	0.00	0.26	-0.06	-0.19	1.54
GWAS Exclusive	EAML	0.01	1.01	1.05	0.60	0.55
EAML Exclusive	GWAS Exclusive	0.00	0.11	-0.03	0.01	0.45
GWAS Exclusive	EAML Exclusive	0.01	-0.15	-0.21	-0.40	-0.36
EAML Exclusive	Overlap	0.00	-0.17	-0.16	-0.25	-0.12
GWAS Exclusive	Overlap	0.04	84.49	182.28	46.52	240.59
Overlap	Exclusives	0.02	2.00	4.19	2.54	7.10

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML Exclusive	100	100	
GWAS Exclusive	76	75	CASC16
Overlap	1	1