Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
consensus	Juan	8.91e-01	6.98e-01	2.18e-01	1.18e-03
Juan	consensus	2.39e-01	2.76e-01	1.32e-02	5.69e-01



Evaluating how well consensus genes are linked to Juan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus	Juan	0.74	0.01	-0.35	0.47	3.62
Juan	consensus	0.49	-1.72	-1.83	-1.01	-0.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus	Juan	0.00	-0.22	-0.78	0.12	1.37
Juan	consensus	0.00	-0.74	-0.69	-0.27	0.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
consensus	47	47	
Juan	12	12