Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
consensus	GWAS	4.64e-01	3.61e-01	8.55e-01	1.26e-01
GWAS	consensus	7.78e-01	7.76e-01	3.13e-01	7.52e-01



Evaluating how well consensus genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus	GWAS	0.55	-0.61	-1.10	-0.71	1.73
GWAS	consensus	0.51	-0.84	-0.42	-0.36	0.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
consensus	GWAS	0.00	0.01	-0.68	-0.25	0.64
GWAS	consensus	0.00	-0.94	-0.36	-0.42	-0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
consensus	47	47	
GWAS	77	76	CASC16