Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EPI_v3Train_01 Exclusive	Tier1Glycemic	2.03e-01	1.25e-01	7.84e-01	9.75e-08
Tier1Glycemic Exclusive	EPI_v3Train_01	3.26e-01	2.79e-01	5.28e-06	9.33e-01
EPI_v3Train_01 Exclusive	Tier1Glycemic Exclusive	3.49e-01	1.33e-01	9.10e-01	1.09e-06
Tier1Glycemic Exclusive	EPI_v3Train_01 Exclusive	1.98e-01	3.96e-01	2.36e-05	8.78e-01
EPI_v3Train_01 Exclusive	Overlap	3.22e-01	5.73e-01	6.73e-01	3.37e-01
Tier1Glycemic Exclusive	Overlap	6.93e-04	7.38e-04	6.93e-04	8.38e-04
Overlap	Exclusives	1.23e-04	1.03e-05	2.21e-13	1.93e-06



Evaluating how well EPI_v3Train_01 genes are linked to Tier1Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_v3Train_01 Exclusive	Tier1Glycemic	0.63	1.42	1.69	1.09	5.87
Tier1Glycemic Exclusive	EPI_v3Train_01	0.50	1.70	1.65	0.99	0.47
EPI_v3Train_01 Exclusive	Tier1Glycemic Exclusive	0.63	1.38	1.86	0.77	5.39
Tier1Glycemic Exclusive	EPI_v3Train_01 Exclusive	0.50	1.18	1.08	0.74	-0.35
EPI_v3Train_01 Exclusive	Overlap	0.64	1.85	1.12	1.59	1.51
Tier1Glycemic Exclusive	Overlap	0.86	4.59	3.53	4.01	3.07
Overlap	Exclusives	0.57	3.65	6.68	3.89	5.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EPI_v3Train_01 Exclusive	Tier1Glycemic	0.01	0.32	0.38	0.22	4.05
Tier1Glycemic Exclusive	EPI_v3Train_01	0.02	5.79	3.59	3.12	3.00
EPI_v3Train_01 Exclusive	Tier1Glycemic Exclusive	0.01	0.32	0.38	-0.11	2.90
Tier1Glycemic Exclusive	EPI_v3Train_01 Exclusive	0.02	1.48	1.08	0.47	-0.40
EPI_v3Train_01 Exclusive	Overlap	0.00	1.43	0.38	1.70	0.17
Tier1Glycemic Exclusive	Overlap	0.06	713.38	162.26	359.87	215.92
Overlap	Exclusives	0.05	13.73	19.78	13.67	18.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EPI_v3Train_01 Exclusive	406	402	GCSAML-AS1;AC018554.3;IQANK1;RNASE4
Tier1Glycemic Exclusive	134	129	LOC440028;LOC101928994;LOC101928448;LOC157273;LINC00261
Overlap	7	7