Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
EAML_v3Train_01 Exclusive	Tier1Glycemic	5.22e-03	5.06e-03	1.11e-01	1.99e-06
Tier1Glycemic Exclusive	EAML_v3Train_01	1.24e-01	2.98e-01	9.88e-04	3.14e-01
EAML_v3Train_01 Exclusive	Tier1Glycemic Exclusive	1.17e-02	8.53e-03	1.41e-01	2.95e-06
Tier1Glycemic Exclusive	EAML_v3Train_01 Exclusive	1.21e-01	5.08e-01	3.04e-03	1.82e-01
EAML_v3Train_01 Exclusive	Overlap	2.30e-01	3.37e-01	4.18e-01	1.62e-01
Tier1Glycemic Exclusive	Overlap	6.46e-02	6.84e-02	2.70e-02	3.69e-02
Overlap	Exclusives	1.54e-05	2.19e-05	6.03e-12	7.95e-06



Evaluating how well EAML_v3Train_01 genes are linked to Tier1Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_v3Train_01 Exclusive	Tier1Glycemic	0.65	2.39	3.19	2.17	6.16
Tier1Glycemic Exclusive	EAML_v3Train_01	0.50	1.81	1.18	1.04	-0.11
EAML_v3Train_01 Exclusive	Tier1Glycemic Exclusive	0.64	2.24	2.88	2.41	5.72
Tier1Glycemic Exclusive	EAML_v3Train_01 Exclusive	0.49	1.36	0.75	0.81	-0.46
EAML_v3Train_01 Exclusive	Overlap	0.73	1.80	1.72	1.50	1.62
Tier1Glycemic Exclusive	Overlap	0.84	2.85	2.30	2.39	2.24
Overlap	Exclusives	0.60	3.58	6.05	2.82	5.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
EAML_v3Train_01 Exclusive	Tier1Glycemic	0.01	3.24	4.26	3.10	4.92
Tier1Glycemic Exclusive	EAML_v3Train_01	0.02	19.99	14.56	9.07	8.75
EAML_v3Train_01 Exclusive	Tier1Glycemic Exclusive	0.01	2.80	3.45	2.97	4.31
Tier1Glycemic Exclusive	EAML_v3Train_01 Exclusive	0.01	3.08	2.38	2.42	1.19
EAML_v3Train_01 Exclusive	Overlap	0.00	9.16	10.70	2.80	2.18
Tier1Glycemic Exclusive	Overlap	0.09	298.36	87.18	632.20	153.25
Overlap	Exclusives	0.04	13.68	31.72	16.11	25.48

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
EAML_v3Train_01 Exclusive	156	151	IQANK1;RNASE4;SPANXB1;TSPY1;GCSAML-AS1
Tier1Glycemic Exclusive	137	132	LOC101928994;LOC101928448;LOC157273;LOC440028;LINC00261
Overlap	4	4