Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Consensus2_v3Train_01 Exclusive	Tier1T2D	7.57e-01	5.14e-01	4.38e-01	1.58e-01
Tier1T2D Exclusive	Consensus2_v3Train_01	1.05e-01	9.58e-01	5.41e-02	2.85e-02
Consensus2_v3Train_01 Exclusive	Tier1T2D Exclusive	1.86e-01	2.36e-01	4.05e-01	3.51e-01
Tier1T2D Exclusive	Consensus2_v3Train_01 Exclusive	7.95e-02	5.88e-01	2.03e-01	5.95e-02
Consensus2_v3Train_01 Exclusive	Overlap	7.64e-02	2.57e-01	1.03e-01	1.74e-01
Tier1T2D Exclusive	Overlap	1.02e-02	1.02e-02	1.10e-02	1.14e-02
Overlap	Exclusives	4.02e-03	2.59e-02	8.46e-06	2.42e-05



Evaluating how well Consensus2_v3Train_01 genes are linked to Tier1T2D genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2_v3Train_01 Exclusive	Tier1T2D	0.59	0.76	0.35	0.28	1.13
Tier1T2D Exclusive	Consensus2_v3Train_01	0.57	-1.15	0.03	-0.27	2.64
Consensus2_v3Train_01 Exclusive	Tier1T2D Exclusive	0.53	-0.52	-0.88	-0.64	0.26
Tier1T2D Exclusive	Consensus2_v3Train_01 Exclusive	0.56	-1.17	-0.75	-0.66	1.92
Consensus2_v3Train_01 Exclusive	Overlap	0.76	2.12	1.53	1.62	1.83
Tier1T2D Exclusive	Overlap	0.90	2.94	2.76	2.90	2.98
Overlap	Exclusives	0.62	1.98	2.55	1.89	5.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Consensus2_v3Train_01 Exclusive	Tier1T2D	0.00	0.52	-0.64	0.05	0.14
Tier1T2D Exclusive	Consensus2_v3Train_01	0.01	1.00	4.33	2.16	4.19
Consensus2_v3Train_01 Exclusive	Tier1T2D Exclusive	0.00	-0.33	-0.79	-0.35	-0.12
Tier1T2D Exclusive	Consensus2_v3Train_01 Exclusive	0.01	-0.74	-0.73	-0.78	0.41
Consensus2_v3Train_01 Exclusive	Overlap	0.00	1.93	1.56	1.06	0.60
Tier1T2D Exclusive	Overlap	0.04	69.97	195.74	83.50	50.11
Overlap	Exclusives	0.01	5.73	8.59	3.81	4.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Consensus2_v3Train_01 Exclusive	117	113	IQANK1;GCSAML-AS1;SPANXB1;RNASE4
Tier1T2D Exclusive	10	10	
Overlap	4	4