Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MetaServer_v3Train_01 Exclusive	Tier1Glycemic	9.57e-01	4.89e-01	3.01e-02	2.03e-05
Tier1Glycemic Exclusive	MetaServer_v3Train_01	7.27e-01	5.63e-01	1.63e-03	2.27e-02
MetaServer_v3Train_01 Exclusive	Tier1Glycemic Exclusive	8.05e-01	3.18e-01	1.89e-02	1.38e-05
Tier1Glycemic Exclusive	MetaServer_v3Train_01 Exclusive	2.62e-01	4.00e-01	7.64e-03	5.08e-02
MetaServer_v3Train_01 Exclusive	Overlap	7.98e-01	7.21e-01	7.84e-01	7.91e-01
Tier1Glycemic Exclusive	Overlap	1.64e-04	1.98e-04	1.64e-04	2.22e-04
Overlap	Exclusives	3.78e-07	4.01e-08	9.62e-08	3.30e-14



Evaluating how well MetaServer_v3Train_01 genes are linked to Tier1Glycemic genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MetaServer_v3Train_01 Exclusive	Tier1Glycemic	0.61	0.19	0.92	0.67	4.34
Tier1Glycemic Exclusive	MetaServer_v3Train_01	0.56	1.29	0.64	0.92	2.49
MetaServer_v3Train_01 Exclusive	Tier1Glycemic Exclusive	0.61	0.25	0.97	0.70	3.82
Tier1Glycemic Exclusive	MetaServer_v3Train_01 Exclusive	0.54	-0.14	-0.35	0.14	1.77
MetaServer_v3Train_01 Exclusive	Overlap	0.59	0.86	0.80	0.47	0.84
Tier1Glycemic Exclusive	Overlap	0.89	4.32	4.00	3.52	3.28
Overlap	Exclusives	0.67	4.98	8.07	5.09	11.61

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MetaServer_v3Train_01 Exclusive	Tier1Glycemic	0.01	0.29	0.12	0.96	1.45
Tier1Glycemic Exclusive	MetaServer_v3Train_01	0.01	12.06	5.94	5.66	10.63
MetaServer_v3Train_01 Exclusive	Tier1Glycemic Exclusive	0.01	0.21	0.02	0.93	1.73
Tier1Glycemic Exclusive	MetaServer_v3Train_01 Exclusive	0.01	-0.02	-0.14	0.44	1.24
MetaServer_v3Train_01 Exclusive	Overlap	0.00	2.59	4.26	1.60	0.33
Tier1Glycemic Exclusive	Overlap	0.07	744.23	170.15	354.64	122.86
Overlap	Exclusives	0.04	26.58	39.58	20.75	40.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MetaServer_v3Train_01 Exclusive	124	123	SPANXB1
Tier1Glycemic Exclusive	135	130	LOC101928994;LOC440028;LOC157273;LOC101928448;LINC00261
Overlap	6	6