Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
MetaServer_v3Train_01 Exclusive	Tier1T2D	5.05e-01	4.71e-01	6.84e-01	6.46e-01
Tier1T2D Exclusive	MetaServer_v3Train_01	3.23e-01	5.70e-01	6.20e-05	4.71e-02
MetaServer_v3Train_01 Exclusive	Tier1T2D Exclusive	1.35e-01	2.02e-01	3.79e-01	6.73e-01
Tier1T2D Exclusive	MetaServer_v3Train_01 Exclusive	1.04e-01	1.98e-01	2.93e-04	1.28e-01
MetaServer_v3Train_01 Exclusive	Overlap	4.23e-01	4.83e-01	2.47e-01	6.13e-01
Tier1T2D Exclusive	Overlap	7.62e-04	7.15e-04	1.01e-03	8.64e-04
Overlap	Exclusives	1.53e-01	5.87e-02	4.71e-02	1.65e-03



Evaluating how well MetaServer_v3Train_01 genes are linked to Tier1T2D genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MetaServer_v3Train_01 Exclusive	Tier1T2D	0.57	-0.02	0.17	-0.20	0.89
Tier1T2D Exclusive	MetaServer_v3Train_01	0.54	-0.60	-0.21	-0.46	1.99
MetaServer_v3Train_01 Exclusive	Tier1T2D Exclusive	0.52	-1.75	-1.41	-1.29	0.13
Tier1T2D Exclusive	MetaServer_v3Train_01 Exclusive	0.53	-1.84	-1.52	-0.94	1.15
MetaServer_v3Train_01 Exclusive	Overlap	0.62	1.14	1.24	1.16	0.98
Tier1T2D Exclusive	Overlap	0.85	3.37	3.78	3.51	3.04
Overlap	Exclusives	0.59	2.30	2.61	2.19	3.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
MetaServer_v3Train_01 Exclusive	Tier1T2D	0.00	0.80	2.26	1.73	1.37
Tier1T2D Exclusive	MetaServer_v3Train_01	0.01	3.22	2.39	1.46	3.36
MetaServer_v3Train_01 Exclusive	Tier1T2D Exclusive	0.00	-1.15	-0.75	-0.81	-0.25
Tier1T2D Exclusive	MetaServer_v3Train_01 Exclusive	0.01	-1.51	-1.39	-1.05	-0.06
MetaServer_v3Train_01 Exclusive	Overlap	0.00	7.70	14.31	7.10	0.31
Tier1T2D Exclusive	Overlap	0.03	113.95	169.47	89.64	21.64
Overlap	Exclusives	0.01	7.05	6.50	5.92	3.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
MetaServer_v3Train_01 Exclusive	123	122	SPANXB1
Tier1T2D Exclusive	7	7	
Overlap	7	7