Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) vep_2method_RareCon_AC5 Exclusive All-Familial 1.50e-08 1.13e-06 2.94e-13 1.46e-16 All-Familial Exclusive vep_2method_RareCon_AC5 4.78e-03 6.10e-02 8.13e-07 9.35e-07 vep_2method_RareCon_AC5 Exclusive All-Familial Exclusive 8.25e-06 1.80e-04 4.00e-09 1.71e-13 All-Familial Exclusive vep_2method_RareCon_AC5 Exclusive 1.05e-02 1.78e-01 2.88e-06 3.63e-05 vep_2method_RareCon_AC5 Exclusive Overlap 3.45e-06 5.05e-05 1.25e-06 4.38e-07 All-Familial Exclusive Overlap 4.18e-08 4.77e-08 4.18e-08 4.37e-08 Overlap Exclusives 1.05e-08 4.87e-07 1.09e-14 1.25e-11 Evaluating how well vep_2method_RareCon_AC5 genes are linked to All-Familial genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) vep_2method_RareCon_AC5 Exclusive All-Familial 0.86 2.46 5.69 2.81 9.33 All-Familial Exclusive vep_2method_RareCon_AC5 0.61 2.20 2.66 2.60 5.18 vep_2method_RareCon_AC5 Exclusive All-Familial Exclusive 0.84 2.38 5.05 3.00 7.28 All-Familial Exclusive vep_2method_RareCon_AC5 Exclusive 0.60 1.72 2.09 1.78 4.68 vep_2method_RareCon_AC5 Exclusive Overlap 0.98 2.80 3.46 2.57 5.04 All-Familial Exclusive Overlap 1.00 2.57 4.48 2.95 5.05 Overlap Exclusives 0.65 1.73 4.00 1.92 8.36 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) vep_2method_RareCon_AC5 Exclusive All-Familial 0.02 0.69 13.99 4.59 32.76 All-Familial Exclusive vep_2method_RareCon_AC5 0.05 24.72 46.68 40.68 56.54 vep_2method_RareCon_AC5 Exclusive All-Familial Exclusive 0.01 -0.28 8.85 2.69 5.37 All-Familial Exclusive vep_2method_RareCon_AC5 Exclusive 0.02 8.07 11.20 8.75 14.98 vep_2method_RareCon_AC5 Exclusive Overlap 0.01 4.39 14.84 9.06 14.01 All-Familial Exclusive Overlap 0.31 45.60 532.93 506.84 291.65 Overlap Exclusives 0.05 10.95 31.30 17.51 35.86 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes vep_2method_RareCon_AC5 Exclusive 189 187 ;PRAMEF11 All-Familial Exclusive 52 52 Overlap 8 8