Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Tier1-Fuchs Exclusive	Tier1-Chen	2.98e-09	1.45e-09	3.36e-09	9.74e-15
Tier1-Chen Exclusive	Tier1-Fuchs	4.25e-07	2.59e-07	3.31e-08	3.53e-07
Tier1-Fuchs Exclusive	Tier1-Chen Exclusive	7.38e-07	3.14e-07	7.75e-07	2.62e-13
Tier1-Chen Exclusive	Tier1-Fuchs Exclusive	6.93e-03	1.16e-02	5.99e-03	1.48e-02
Tier1-Fuchs Exclusive	Overlap	4.18e-06	4.02e-06	4.51e-06	7.63e-06
Tier1-Chen Exclusive	Overlap	3.20e-06	8.84e-06	2.64e-06	4.34e-06
Overlap	Exclusives	9.65e-13	6.81e-14	1.78e-17	1.39e-18



Evaluating how well Tier1-Fuchs genes are linked to Tier1-Chen genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Fuchs Exclusive	Tier1-Chen	0.74	4.37	7.65	4.30	9.58
Tier1-Chen Exclusive	Tier1-Fuchs	0.89	5.37	6.48	4.88	4.63
Tier1-Fuchs Exclusive	Tier1-Chen Exclusive	0.73	4.21	6.75	4.14	8.73
Tier1-Chen Exclusive	Tier1-Fuchs Exclusive	0.86	4.67	4.21	3.38	3.05
Tier1-Fuchs Exclusive	Overlap	0.90	3.74	3.98	3.48	3.61
Tier1-Chen Exclusive	Overlap	0.92	4.27	4.62	3.79	3.76
Overlap	Exclusives	0.76	6.13	8.01	4.92	10.58

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Fuchs Exclusive	Tier1-Chen	0.03	16.75	27.49	17.66	18.46
Tier1-Chen Exclusive	Tier1-Fuchs	0.11	290.79	279.45	290.91	135.37
Tier1-Fuchs Exclusive	Tier1-Chen Exclusive	0.02	12.00	18.76	10.77	14.27
Tier1-Chen Exclusive	Tier1-Fuchs Exclusive	0.01	72.29	63.60	40.01	37.67
Tier1-Fuchs Exclusive	Overlap	0.02	71.83	78.25	35.65	36.47
Tier1-Chen Exclusive	Overlap	0.12	177.80	158.31	453.23	240.46
Overlap	Exclusives	0.08	62.62	103.83	56.77	105.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Tier1-Fuchs Exclusive	6	6	
Tier1-Chen Exclusive	133	128	LINC00261;LOC157273;LOC440028;LOC101928994;LOC101928448
Overlap	8	8