Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Tier1-Fuchs Exclusive	MalaCard	7.99e-09	8.75e-10	1.39e-08	6.07e-15
MalaCard Exclusive	Tier1-Fuchs	1.54e-06	5.61e-06	1.89e-07	1.74e-06
Tier1-Fuchs Exclusive	MalaCard Exclusive	1.43e-06	7.02e-07	2.93e-06	1.16e-11
MalaCard Exclusive	Tier1-Fuchs Exclusive	3.92e-03	4.47e-03	4.13e-03	1.21e-02
Tier1-Fuchs Exclusive	Overlap	1.70e-05	1.63e-05	7.91e-06	1.07e-05
MalaCard Exclusive	Overlap	2.62e-06	2.62e-06	2.62e-06	2.62e-06
Overlap	Exclusives	1.52e-19	1.79e-19	8.10e-21	1.88e-20



Evaluating how well Tier1-Fuchs genes are linked to MalaCard genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Fuchs Exclusive	MalaCard	0.90	3.58	8.26	3.43	8.24
MalaCard Exclusive	Tier1-Fuchs	0.87	4.64	4.25	3.63	4.92
Tier1-Fuchs Exclusive	MalaCard Exclusive	0.88	3.19	5.58	2.79	6.94
MalaCard Exclusive	Tier1-Fuchs Exclusive	0.78	3.61	3.69	2.76	2.55
Tier1-Fuchs Exclusive	Overlap	0.98	3.25	4.04	3.02	4.31
MalaCard Exclusive	Overlap	1.00	2.79	3.69	3.48	4.14
Overlap	Exclusives	0.94	4.35	9.59	4.68	9.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Tier1-Fuchs Exclusive	MalaCard	0.02	24.58	31.01	21.87	11.05
MalaCard Exclusive	Tier1-Fuchs	0.25	222.18	648.45	377.60	189.56
Tier1-Fuchs Exclusive	MalaCard Exclusive	0.01	14.61	20.36	9.15	13.67
MalaCard Exclusive	Tier1-Fuchs Exclusive	0.00	0.96	21.21	6.08	6.09
Tier1-Fuchs Exclusive	Overlap	0.01	30.89	26.74	13.51	17.20
MalaCard Exclusive	Overlap	0.55	370.57	916.72	1067.42	1737.35
Overlap	Exclusives	0.11	71.54	253.10	131.48	216.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Tier1-Fuchs Exclusive	8	8	
MalaCard Exclusive	26	26	
Overlap	6	6